INTRAVENOUS TRYPSIN: ITS ANTICOAGULANT, FIBRINOLYTIC AND THROMBOLYTIC EFFECTS 1

Anticoagulant, Antiplatelet, and Fibrinolytic (Thrombolytic) Drugs

Little intravascular coagulation of blood occurs in normal physiological conditions. Hemostasis involves the interplay of three procoagulant phases (vascular, platelet, and coagulation) that promote blood clotting to prevent blood loss (Fig. 22.1). The fibrinolytic system prevents propagation of clotting beyond the site of vascular injury and is involved in clot dissolution, or lysis (Fig. 22.2...

The Anticoagulant and Fibrinolytic Systems

Antiplatelet, anticoagulant, and thrombolytic drug interactions.

2112. 13. Lassen, M. R. (2000) The EPHESUS study: comparison of the first synthetic factor Xa inhibitor with low molecular weight heparin (LMWH). The prevention of venous thromboembolism (VTE) after elective hip replacement surgery. Blood96(11), Abstract #2109. 14. Erickson, B. (2000) The PENTHIFRA study: comparison of the first synthetic Factor Xa inhibitor with low molecular weight hepari...

Fibrinolytic Bacterial Enzymes with Thrombolytic Activity

This book describes the fibrinolytic enzymes of microbial origin that are able to dissolve endogenous thrombi in vivo. The fibrinolytic enzyme streptokinase for example, is produced by b-hemolytic streptococci and exerts its enzyme action indirectly by activating plasminogen. On the other hand, staphylokinase is produced by Staphylococcus aureus by stoichiometric complexation with plasmin(ogen)...

Fibrinolytic Bacterial Enzymes with Thrombolytic Activity

This book describes the fibrinolytic enzymes of microbial origin that are able to dissolve endogenous thrombi in vivo. The fibrinolytic enzyme streptokinase for example, is produced by b-hemolytic streptococci and exerts its enzyme action indirectly by activating plasminogen. On the other hand, staphylokinase is produced by Staphylococcus aureus by stoichiometric complexation with plasmin(ogen)...